Guide for The Binding of Isaac: Rebirth (2024)

This final page will cover all of the endings for The Binding of Isaac as well as every secret. Both game endings and all secrets are necessary to complete each version of the game 100%.

Endings

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Epilogue - Unlocked after defeating Mom for the first time.

Endings 1-11 - Unlocked one at a time each time you defeat Mom's Heart.

Ending 12 - Unlocked by clearing Sheol and defeating Satan for the first time.

Ending 13 - Unlocked by clearing The Cathedral and defeating Isaac for the first time.

Ending 14 - Unlocked by clearing The Chest and defeating Blue Baby (???) for the first time.

Ending 15 - Unlocked by clearing The Dark Room and defeating The Lamb for the first time.

Once the first 15 endings are unlocked in Rebirth you will unlock:

Golden God
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Ending 16 - Unlocked by defeating Mega Satan for the first time.

Ending 17 (Afterbirth) - Unlocked by defeating Hush for the first time.

Ending 18 (Afterbirth) - Unlocked by defeating Ultra Greed in Greed Mode for the first time.

Ending 19 (Afterbirth+) - Unlocked by defeating Ultra Greed in Greedier Mode for the first time.

Final Ending (Afterbirth+) - Unlocked by defeating Delirium for the first time.

Secrets

Secrets are essentially in-game achievements. As of Afterbirth+ there are 178 and all are needed for PG, RPG and 1001%. A lot of these will likely be repeated on other pages as they are also tied to some achievements. I won't go into great detail unless it is necessary and not explained elsewhere.

Rebirth

Magdalene - Have 7 or more red heart containers at once

Cain - Have 55 coins at one time

Judas - Defeat Satan for the first time

The Womb - Defeat Mom for the first time

The Harbingers - Defeat Mom for the first time

A Cube of Meat - Defeat Mom for the first time

Book of Revelations - Defeat a Harbinger for the first time

A Noose - Defeat Mom's Heart 3 times

The Nail - Complete Boss Rush as Azazel

A Quarter - Defeat Mom's Heart 8 times

A Fetus in a Jar - Defeat Mom's Heart 9 times

A Small Rock - Destroy 100 tinted rocks

Monstro's Tooth - Beat Chapter 1 for the first time

Lil' Chubby - Beat Chapter 2 for the first time

Loki's Horns - Defeat Lokii for the first time

Something from the Future - Beat The Basem*nt 40 times

Something Cute - Beat Chapter 2 30 times

Something Sticky - Beat Chapter 3 20 times

A Bandage - Make a Super Bandage Girl by collecting 4 Balls of Bandages. Balls of Bandages can only be found by defeating a Harbinger boss (Famine, Pestilence, War and Death). The easiest way to do this is to restart your run until you get the Book of Revelation in either the Item Room or a Library. Whenever you use the Book of Revelations, it forces one of the bosses for the current chapter to be one of the four Harbinger bosses. The Harbingers are necessary as they always drop either Cube of Meat or Ball of Bandages. If they drop Cube of Meat, restart and try again. Always use it on the first floor of a chapter to be safe. Unfortunately, even this strategy is not fool proof as double trouble boss rooms cannot be changed and you cannot force the fight instead of Mom or Mom's Heart. The last obstacle comes with Womb I which has a chance to spawn the Harbinger called Conquest instead of Death. If this happens, you must restart as Conquest will only ever drop the White Pony item. With a bit of luck and perseverance you will eventually get all four Balls of Bandages to create Super Bandage Girl.

A Cross - Defeat Isaac as Magdalene

A Bag of Pennies - Defeat Isaac as Cain

The Book of Sin - Defeat all 7 Deadly Sin mini-bosses

Little Gish- Defeat Gish for the first time

Little Steven - Defeat Steven for the first time

Little C.H.A.D. - Defeat C.H.A.D. for the first time

A Gamekid - Visit 10 Arcade rooms

A Halo - Defeat Mom using The Bible

Mr. Mega - Destroy 10 tinted rocks

The D6 - Defeat Isaac as Blue Baby

The Scissors - Die 100 times

The Parasite - Pick up any two of the following in one run - Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head

??? - Defeat Mom's Heart 10 times

Everything is Terrible - Defeat Mom's Heart 5 times

It Lives! - Defeat Mom's Heart 11 times

Mom's Contact - Become Mom (pick up any 3 Mom themed items in one run, doesn't trigger transformation in Rebirth)

The Necronomicon - Use the Death card 4 times over multiple runs

Basem*nt Boy - Beat Chapter 1 without taking any damage

Spelunker Boy - Beat Chapter 2 without taking any damage

Dark Boy - Beat Chapter 3 without taking any damage

Mama's Boy - Beat Chapter 4 without taking any damage

Golden God - Defeat ??? and The Lamb for the first time

Eve - Don't pick up any hearts for two floors in a row.

Mom's Knife - Defeat Satan as Isaac

The Razor - Defeat Satan as Eve

Guardian Angel - Defeat Satan as Magdalene

A Bag of Bombs - Defeat Satan as Cain

Demon Baby - Defeat The Lamb as Azazel

Forget Me Now - Defeat Satan as Blue Baby

The D20 - Defeat ??? as Isaac

Celtic Cross - Defeat ??? as Magdelene

Abel - Defeat The Lamb as Judas

Curved Horn - Defeat The Lamb as Judas

Sacrificial Dagger - Defeat ??? as Eve

Bloody Lust - Defeat Isaac as Satan

Blood Penny - Defeat ??? as Samson

Blood Rights - Defeat Satan as Samson

The Polaroid - Defeat Isaac 5 times

Dad's Key - Pick up both Key Pieces from the Angels in one run (Complete the Mega Satan door key)

Blue Candle - Donate 900 pennies to the shop Donation Machine

Burnt Penny - Beat Challenge #13

Lucky Toe - Blow up 20 shopkeepers

Epic Fetus - Beat Challenge 19

SMB Super Fan - Beat Challenge #14

Counterfeit Coin - Play the Shell Game Bum 100 times

Guppy's Hairball - Become Guppy for the first time

A Forgotten Horsem*n - Take 10 items from Angel Rooms

Samson - Beat 2 floors in a row without taking damage

Something Icky - Defeat Isaac 10 times

Platinum God - Collect all items in the game, unlock all secrets and endings not including The Lost and his 6 unlockable items

Isaac's Head - Complete Boss Rush as Isaac

Maggy's Faith - Defeat the Lamb as Magdelene

Judas' Tongue - Defeat Satan as Judas